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The limitation of their experimental design was the unstable con-struct using a Kirschner wire in the tibia without interlocking bolt. If insulin is not exogenouslyadministered cheap diflucan the body will attempt to utilize other energy sources, which results inketone formation and, especially with any perpetuating factors (such as stress), ketoaci-dosis.
In this case, the investigator repeatsthe research with the same subjects or a new group of subjects to confirm the reliability ofthe original results and test their generality within the limits of type of subjects, settings,and measurements. Oxford Centre forevidence-based medicine: Levels of evidence.
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